💊SiderAL Folico💊Sucrosomial Iron Plus Folic Acid. High Absorption. 30 sach.

General Info:

Iron is an essential element for life and therefore its homeostasis is crucial for our health. Our organism can use iron in the following two processes: 

1. Mitochondrial functions
2. Transport of oxygen

Our bodies do not contain mechanisms for controlling the excretion of iron, thus regulation of iron levels occurs only during the absorption process, in combination with the recycling mechanisms and the utilisation sites. The homeostatic control of iron is mainly made by the intestinal epithelium which actively absorbs iron from food. Despite the fact that only a small amount of iron is absorbed, this process is well regulated by a negative feedback mechanism in accordance to the iron levels inside the body. Generally, the amount absorbed is around 2mg which counters the loss of iron though urine, faces, sweat and even dead skin cells. Women have an extra loss due to their menstrual cycle.

The term, folic acid, carries different meaning between scientific fields. In the field of nutrition, folic acid refers to the synthetic form of essential nutrient (also called B9), usually given as a supplement.

Nutritional Info: Dietary iron exists in two forms, heme and non-heme iron. Heme is maintained soluble by pancreatic enzymes while non-heme form gets precipitated by numerous dietary constituents that render it non-absorbable. Ascorbic acid, which is commonly co administrated with iron supplements, increases ferric and ferrous salts absorption, by chelating iron and thus preventing other compounds from attaching and making it unavailable.

Animal sources contain mainly heme iron and include meat, poultry, seafood and eggs. Plant-based sources of iron contain non-heme forms and include legumes, tofu, nuts, brown rice and whole grain cereals.

The RDI of iron depends your age and sex. Generally, an adult man needs around 8mg while women below 50 around 18mg.

Coffee, tea, red wine and calcium-rich foods, are common examples of food that can inhibit iron absorption.

The biological activity of folate in the body depends upon dihydrofolate reductase action. This enzyme is located in the liver, where it converts folate into tetrahydrofolate (THF). This action is rate-limiting in humans leading to elevated blood concentrations of unmetabolized folic acid when consumption from dietary supplements and fortified foods nears or exceeds the Tolerable Upper Intake Level. Generally supplementes contain 400 to 800 mcg folic acid.

Description:

Pharmaceutical Technology: An iron containing supplement with a patented SiderAl technology based on a sucrosomial formulation (with phospholipids,emulsifiers, fatty acid esters). A liposome is a spherical vesicle containing at least one lipid bilayer. This structure can be loaded with hydrophobic and/or hydrophilic molecules and deliver them effectively by fusing with other bilayers such as the cell membrane. This method increases the absorption rate while also minimises many adverse effects. In the case of iron, constipation which is a common complain during therapies, can be avoided since iron does not come in direct contact with the intestinal mucosa.

Folic acid absorption in supplements its around 85% and can reach 100% if taken with food. In the case of SiderAl Folico, reason dictates that the absorption is higher than other non sucrosomial formulations.

• Product must be kept in temperatures <25°C
• Keep in cool, dry place
• Do not exceed daily dose
• No to be used in children below the age of 3
• Does not contain gluten
• Contains polyoles which can have a small laxative effect

Ingredients per daily dose

Iron             21.00mg

Vitamin C   70.00g

Folic acid    400.00mcg

Vitamin D   10mcg

Vitamin B6 1.00mg

How to use:

Dossage: 1 sachet per day dissolved directly in the mouth

Clinical Advice:

As always, our decisions should be based on evidence. Like all the supplements, SiderAl Folico should not replace an approved medicinal form of iron. Also, improving your understanding around iron supplements and iron physiology through internet, should not replace your GPs expert opinion. Nevertheless, for people who are healthy or they have a small reduction in their hematocrit levels (HCT), or people who can not tolerate other forms of iron or even women with heavy periods, this supplement is a clearly safe choice and from my working experience i can guarantee that patients love it. The addition of folic acid makes the supplement more targeted for situations like pregancy, periods and for the elderly. Also, the product can be used for people with alcohol use disorder, since they frequently have poor-quality diets that contain insufficient amounts of folate. Moreover, alcohol interferes with folate absorption and hepatic uptake, accelerates folate breakdown, and increases its renal excretion. Personally, i grade SiderAl series of products at the top three supplements i know.

Evidence:

Karavidas A, Troganis E, Lazaros G, Balta D, Karavidas IN, Polyzogopoulou E, Parissis J, Farmakis D. Oral sucrosomial iron improves exercise capacity and quality of life in heart failure with reduced ejection fraction and iron deficiency: a non-randomized, open-label, proof-of-concept study. Eur J Heart Fail. 2021 Apr;23(4):593-597. doi: 10.1002/ejhf.2092. Epub 2021 Jan 22. PMID: 33421230.

Fabiano A, Brilli E, Mattii L, Testai L, Moscato S, Citi V, Tarantino G, Zambito Y. Ex Vivo and in Vivo Study of Sucrosomial^® Iron Intestinal Absorption and Bioavailability. Int J Mol Sci. 2018 Sep 12;19(9):2722. doi: 10.3390/ijms19092722. PMID: 30213039; PMCID: PMC6165425.

Visciano B, Nazzaro P, Tarantino G, Taddei A, Del Rio A, Mozzillo GR, Riccio E, Capuano I, Pisani A. Il ferro liposomiale: una nuova proposta per il trattamento dell'anemia nei pazienti affetti da insufficenza renale cronica [Liposomial iron: a new proposal for the treatment of anaemia in chronic kidney disease]. G Ital Nefrol. 2013 Sep-Oct;30(5):gin/30.5.7. Italian. PMID: 24402627.